Fix Cisco ASDM Windows 10 Error "This app can't run on your PC"

 Seems that Microsoft has done some switching of how the Windows Scripting Host path is found.

This is a simple fix.

1. Install ASDM as you normally would

2. Right click on the shortcut.

3. In the "Target" line you will see a very long path to wscript.exe.  Simply change this path to C:\Windows\System32\wscript.exe (leave the invisible.vbs run.bat on the end as these scripts are used to open ASDM).

4. Apply the change.

After doing this I was able to open ASDM normally and use it to update ASDM and AnyConnect files on my ASA.

Good luck!